Tg(MGMT)708Tis
Transgene Detail

Summary

• Symbol: Tg(MGMT)708Tis
• Name: transgene insertion 708, Takatoshi Ishikawa
• MGI ID: MGI:3043563
• Synonyms: 100-copy line
• Transgene: Tg(MGMT)708Tis Location: unknown
• Alliance: Tg(MGMT)708Tis page

Transgene origin

• Strain of Origin: C3H/HeN

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains the Chinese hamster MT1 (metallothionein 1) promoter and an allele of the bacterial ada (0⁶-methylguanine DNA methyltransferase) gene. Line 708 integrated approximately 100 copies of the transgene into the genome. After treatment with heavy metals, enzyme activity is detected in liver of transgenic mice. (J:90320)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Founder numbers 604 and 708 were produced.

References

• Original: J:90320 Matsukuma S, et al., Enhanced O6-methylguanine-DNA methyltransferase activity in transgenic mice containing an integrated E. coli ada repair gene. Mutat Res. 1989 Nov;218(3):197-206
• All: 4 reference(s)