Epfpq3^L6
QTL Variant Detail

Summary

• QTL variant: Epfpq3^L6
• Name: epididymal fat percentage QTL 3; L6
• MGI ID: MGI:3043143
• QTL: Epfpq3 Location: Chr15:78601103-102901704 bp Genetic Position: Chr15, Syntenic

Variant origin

• Strain of Specimen: L6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased epididymal fat percentage compared to M16i. (J:87793)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Epfpq3 may also be consistent with an additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87793

Linkage analysis was performed on 552 10-week old male animals from a (M16i x L6)F2 intercross to identify QTLs associated with measurements of growth such as organ weight, growth rate, and adiposity. 63 polymorphic markers spanning the 19 autosomes wereused in the genome scan. Parental strain M16i is a long term selection line for rapid 3- and 6- week weight gain whereas parental strain L6 is a long term selection line for low 6-week body weight. A total of 50 significant QTLs (LOD>3.3) were mapped over 15 chromosomes. More than 25% of loci mapped to mouse Chromosome 2.

On mouse Chromosome 15, QTLs for subcutaneous fat pad weight (Scfq2) and epididymal fat percentage (Epfpq3, Epfpq4) were identified. Scfq2 mapped to 25.2 cM (LOD=4.4) between D15Mit13 and D15Mit1 with L6-derived alleles conferring recessively inherited increase in subcutaneous fat pad weight. The confidence interval of Scfq2 spans 8.8 cM - 39.6 cM. Epfpq4 mapped to 33.4 cM (LOD=3.4) between D15Mit13 and D15Mit1 and Epfpq3 mapped to 51.1 cM (LOD=3.6) between D15Mit1 and D15Mit15. L6-derived alleles confer recessively inherited increase in epididymal fat percentage at both Epfpq3 and Epfpq4. The confidence interval of Epfpq4 spans 21.1 cM - 46.3 cM.

References

• Original: J:87793 Rocha JL, et al., A large-sample QTL study in mice: II. Body composition. Mamm Genome. 2004 Mar;15(2):100-13
• All: 1 reference(s)