Rps6ka3^tm1Kry
Targeted Allele Detail

Summary

• Symbol: Rps6ka3^tm1Kry
• Name: ribosomal protein S6 kinase polypeptide 3; targeted mutation 1, Gerard Karsenty
• MGI ID: MGI:3042584
• Gene: Rps6ka3 Location: ChrX:158038652-158151240 bp, + strand Genetic Position: ChrX, 73.27 cM
• Alliance: Rps6ka3^tm1Kry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89403
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neo cassette, as well as three stop codons in three different frames, was inserted into exon 2. Western blot indicated absence of normal protein in mutant cells. (J:89403)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rps6ka3 Mutation: 12 strains or lines available

References

• Original: J:89403 Yang X, et al., ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell. 2004 Apr 30;117(3):387-98
• All: 1 reference(s)