Stard3^tm1Jfs
Targeted Allele Detail

Summary

• Symbol: Stard3^tm1Jfs
• Name: StAR related lipid transfer domain containing 3; targeted mutation 1, Jerome F Strauss III
• MGI ID: MGI:3042568
• Synonyms: MLN64-
• Gene: Stard3 Location: Chr11:98249245-98271938 bp, + strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Stard3^tm1Jfs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89362
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 10 - 13 were replaced with an IRES-lacZ-Neo fusion gene. This resulted in deletion of most of the StAR-related lipid transfer domain. A truncated 35 kDa protein consisting of exons 1 - 9 fused to exon 14 and containing a frame shift in exon 14 was detected by western blot analysis (J:89362)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stard3 Mutation: 30 strains or lines available

References

• Original: J:89362 Kishida T, et al., Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism. J Biol Chem. 2004 Apr 30;279(18):19276-85
• All: 1 reference(s)