Thyls2^MSM
QTL Variant Detail

Summary

• QTL variant: Thyls2^MSM
• Name: thymic lymphoma susceptibility 2; MSM
• MGI ID: MGI:3042407
• QTL: Thyls2 Location: Chr5:93445064-93445225 bp Genetic Position: Chr5, cM position of peak correlated region/allele: 47.29 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: MSM

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to gamma-irradiation induced thymic lymphomas compared to BALB/c. (J:87704)
• Inheritance: Not Specified

Notes

Animals homozygous for this allele exhibit 87.5% lymphoma incidence compared to 46% in heterozygous animals.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87704

A congenic line carrying a 28.4 cM region of MSM-derived DNA from D5Mit4 (20 cM) to D5Mit315 (59 cM) on a BALB/c genetic background was constructed. This region contains a putative thymic lymphoma susceptibility QTL at 36 cM near D5Mit5 (mapped in a previous study). Animals from a (BALB.MSM-D5Mit4-D5Mit315 x BALB/c)F1 x MSM cross were used to confirm and fine map the locus. 95 animals were subjected to gamma-irradiation and 48 animals were exposed to MNU to induce thymic lymphomas. Parental strain BALB/c is susceptible to gamma-irradiation induced thymic lymphomas whereas parental strain MSM is resistant.

There was significant correlation between the MSM allele at D5Mit7 (45 cM) and incidence of gamma-irradiation induced thymic lymphomas. This locus is named Thyls2 (thymic lymphoma susceptibility 2). BALB/c-derived alleles at Thyls2 appear to confer resistance to gamma-irradiation induced thymic lymphomas. Thyls2 did not show significant correlation to MNU induced thymic lymphomas. Thyls2 maps near a previously QTL named Cypr3 (cytokine production 3, 52 cM). Sod3 is a candidate gene mapping near Thyls2. Sequence analysis of Sod3 revealed a polymorphism resulting in an asparagine (BALB/c) to aspartic acid (MSM) substitution at residue 21.

References

• Original: J:87704 Kodama Y, et al., The D5Mit7 locus on mouse chromosome 5 provides resistance to gamma-ray-induced but not N-methyl-N-nitrosourea-induced thymic lymphomas. Carcinogenesis. 2004 Jan;25(1):143-8
• All: 1 reference(s)