Poo
Spontaneous Allele Detail

Summary

• Symbol: Poo
• Name: primary oocyte ovulation
• MGI ID: MGI:3040786
• Synonyms: Poo^l
• Gene: Poo Location: unknown
• Alliance: Poo page

Mutation origin

• Strain of Origin: LT/SvKau

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• A molecular analysis of this allele has not been reported.
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Poo Mutation: 0 strains or lines available

Notes

LT/SvKau mice ovulate a high proportion of diploid primary oocytes rather than secondary oocytes. Arrested at meitoic metaphase I, these diploid primary oocytes can be fertilized to produce triploid embryos. The frequency of triploidy in a cross with C57BL/Ws is consonant with autosomal codominant inheritance of primary oocyte ovulation. Mutant allele Poo from the LT/SvKau strain shows incomplete penetrance and variable expressivity. In a heterozygote with a normal allele from C57BL/Ws, a small but consistent frequency of primary oocyte ovulation was found (J:30752).

References

• Original: J:17685 West JD, et al., Inheritance of a meiotic abnormality that causes the ovulation of primary oocytes and the production of digynic triploid mice. Genet Res. 1993 Dec;62(3):183-93
• All: 2 reference(s)