Vsx1^tm1Bhr
Targeted Allele Detail

Summary

• Symbol: Vsx1^tm1Bhr
• Name: visual system homeobox 1; targeted mutation 1, Richard R Behringer
• MGI ID: MGI:3040317
• Synonyms: Vsx1^-
• Gene: Vsx1 Location: Chr2:150522622-150531057 bp, - strand Genetic Position: Chr2, 74.74 cM
• Alliance: Vsx1^tm1Bhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89292
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Targeting took place in ES cells carrying a cre transgene Tg(Prm-cre)70Og, which expresses Cre recombinase under control of the male-germline specific protamine promoter. A floxed neo cassette replaced the coding region for the entire homeodomain and CVC domain, leaving fragments of exons 1 and 5 intact. Cre-mediated excision removed the neo cassette upon transmission from male chimeras. (J:89292)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vsx1 Mutation: 10 strains or lines available

References

• Original: J:89292 Ohtoshi A, et al., Regulation of retinal cone bipolar cell differentiation and photopic vision by the CVC homeobox gene Vsx1. Curr Biol. 2004 Mar 23;14(6):530-6
• All: 1 reference(s)