L1cam^tm1Vlem
Targeted Allele Detail

Summary

• Symbol: L1cam^tm1Vlem
• Name: L1 cell adhesion molecule; targeted mutation 1, Vance Lemmon
• MGI ID: MGI:3040292
• Synonyms: L1-6DloxP, L1loxP
• Gene: L1cam Location: ChrX:72897384-72924843 bp, - strand Genetic Position: ChrX, 37.43 cM, cytoband A6-B
• Alliance: L1cam^tm1Vlem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89300
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 12 through 14 were flanked by loxP sites and a neo cassette was inserted 5' of exon 15 via homologous recombination. Flow cytometry indicated that mutant splenic lymphocytes had similar protein expression to that of wild-type mice. (J:89300)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any L1cam Mutation: 11 strains or lines available

References

• Original: J:89300 Itoh K, et al., Brain development in mice lacking L1-L1 homophilic adhesion. J Cell Biol. 2004 Apr12;165(1):145-54
• All: 1 reference(s)