Tg(JCVCY)FF6Kkh
Transgene Detail

Summary

• Symbol: Tg(JCVCY)FF6Kkh
• Name: transgene insertion FF6, Kamel Khalili
• MGI ID: MGI:3040250
• Transgene: Tg(JCVCY)FF6Kkh Location: unknown
• Alliance: Tg(JCVCY)FF6Kkh page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains the Jamestown Canyon virus early gene promoter and the CY allele of the Tag (JCV T antigen) gene. The construct was designated "JCV(CY)." (J:52961)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Founders BB4, FF6 and II4 were selected for biochemical evaluation. Founders BB4, FF6, HH6 and II2 were evaluated histopathologically. Founder number(s) were not specified for tumor data.

The viral strain carrying this T antigen allele has been designated as the archetype strain of this virus.

Mice carrying this transgene develop hindbrain and spinal cord medulloblastomas.

References

• Original: J:52961 Krynska B, et al., Human ubiquitous JCV(CY) T-antigen gene induces brain tumors in experimental animals. Oncogene. 1999 Jan 7;18(1):39-46
• All: 2 reference(s)