Tg(NF2d39)27Gth
Transgene Detail

Summary

• Symbol: Tg(NF2d39)27Gth
• Name: transgene insertion 27, Gilles Thomas
• MGI ID: MGI:3039722
• Synonyms: P0Schdelta39-121
• Transgene: Tg(NF2d39)27Gth Location: unknown
• Alliance: Tg(NF2d39)27Gth page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene contains a cDNA encoding the human neurofibromatosis type 2 protein (Schwannomin) with an internal deletion (amino acids 39-121), and tagged with the 11 C-terminal amino acids of the VSV-G protein. Expression is driven by the rat myelin protein zero promoter. (J:54466)

Tumor Data

List all tumor models in MMHCdb carrying Tg(NF2d39)27Gth

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Founder number not specified (either 6, 25, 27, or 32). Mice carrying this transgene are also called P0-Sch-delta(39-121).

References

• Original: J:54466 Giovannini M, et al., Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein. Genes Dev. 1999 Apr 15;13(8):978-86
• All: 7 reference(s)