Eda2r^tm1Vmd
Targeted Allele Detail

Summary

• Symbol: Eda2r^tm1Vmd
• Name: ectodysplasin A2 receptor; targeted mutation 1, Vishva M Dixit
• MGI ID: MGI:3039665
• Synonyms: EDA2R-KO
• Gene: Eda2r Location: ChrX:96377446-96420822 bp, - strand Genetic Position: ChrX, 42.74 cM
• Alliance: Eda2r^tm1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87681
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The region in exon 4 that encodes the transmembrane domain was replaced with a neo cassette. Western blot analysis confirmed the absence of protein expression. (J:87681)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eda2r Mutation: 8 strains or lines available

References

• Original: J:87681 Newton K, et al., Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiency. Mol Cell Biol. 2004 Feb;24(4):1608-13
• All: 3 reference(s)