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Gypatm1Skmz
Targeted Allele Detail
Summary
Symbol: Gypatm1Skmz
Name: glycophorin A; targeted mutation 1, Kazuhisa Sekimizu
MGI ID: MGI:3039642
Synonyms: GPA-
Gene: Gypa  Location: Chr8:81220674-81237414 bp, + strand  Genetic Position: Chr8, 38.27 cM
Alliance: Gypatm1Skmz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89319
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin cassette replaced exons encoding the transmembrane domains. RT-PCR analysis demonstrated that no detectable transcript was expressed from this allele. PAS staining of erythrocyte membrane proteins confirmed the absence of encoded protein. (J:89319)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gypa Mutation:  21 strains or lines available
References
Original:  J:89319 Arimitsu N, et al., Glycophorin A requirement for expression of O-linked antigens on the erythrocyte membrane. Genes Cells. 2003 Sep;8(9):769-77
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
09/24/2024
MGI 6.24
The Jackson Laboratory