Tg(IgTp-ras)11Yik
Transgene Detail

Summary

• Symbol: Tg(IgTp-ras)11Yik
• Name: transgene insertion 11, Yoji Ikawa
• MGI ID: MGI:3039554
• Transgene: Tg(IgTp-ras)11Yik Location: unknown
• Alliance: Tg(IgTp-ras)11Yik page

Transgene origin

• Strain of Origin: (C57BL/6CrSlc x CD-1)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains the simian virus 40 early gene promoter (viral) and an allele of the human Harvey rat sarcoma virus oncogene that contains a deletion of exon 1 and part of intron 1, and carries an activating point mutation in codon 12 (Gly12Val). The construct also contains mouse immunoglobulin heavy chain complex enhancer sequences. (J:46455)

Tumor Data

List all tumor models in MMHCdb carrying Tg(IgTp-ras)11Yik

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Additional lines were generated, including lines 2, 3, 4, 7, 8, 9, and 11. No tumors were found in mice carrying line 3 or line 10; the other lines were associated with 100% tumor frequency.

References

• Original: J:46455 Suda Y, et al., Driven by the same Ig enhancer and SV40 T promoter ras induced lung adenomatous tumors, myc induced pre-B cell lymphomas and SV40 large T gene a variety of tumors in transgenic mice. EMBO J. 1987 Dec 20;6(13):4055-65
• All: 1 reference(s)