Tlr9^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tlr9^M1Btlr
• Name: toll-like receptor 9; mutation 1, Bruce Beutler
• MGI ID: MGI:3038816
• Synonyms: CpG1, Tlr9^CpG1, unmethylated CpG-oligodeoxynucleotide unresponsive 1
• Gene: Tlr9 Location: Chr9:106099797-106104075 bp, + strand Genetic Position: Chr9, 57.46 cM
• Alliance: Tlr9^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: T to C transition at position 1496 results in a substitution of Leucine for Proline at amino acid 499. (J:88906)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr9 Mutation: 65 strains or lines available

References

• Original: J:88906 Tabeta K, et al., Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3516-21
• All: 13 reference(s)