Tg(Prnp)e19hCwe
Transgene Detail

Summary

• Symbol: Tg(Prnp)e19hCwe
• Name: transgene insertion e19h, Charles Weissmann
• MGI ID: MGI:3038611
• Synonyms: pPrPdeltaNco, Tg(Prnp)E1931Cwe
• Transgene: Tg(Prnp)e19hCwe Location: unknown
• Alliance: Tg(Prnp)e19hCwe page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp)e19hCwe expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prnp (MGI:97769)

• Mutation details: To define the requirements of the prion protein for conferring susceptibility to scrapie, deletion mutants of the mouse Prnp gene were constructed and used to generate transgenic mice on a background homozygous for a targeted mutation of the endogenous Prnp gene. In this transgenic line, the sequence encoding two of the five copies of the octa repeat (amino acids 68-83) was deleted, in addition to the larger of the two introns. (J:32214)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Two founder lines were generated, E19h and E19l. Both lines were capable of restoring susceptibility to scrabies in Prnp nul mutants

References

• Original: J:32214 Fischer M, et al., Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J. 1996 Mar 15;15(6):1255-64
• All: 2 reference(s)