Hdp2^Jrt
Chemically induced Allele Detail

Summary

• Symbol: Hdp2^Jrt
• Name: high doppler 2; high doppler 2, Janet Rossant
• MGI ID: MGI:3037032
• Gene: Hdp2 Location: unknown Genetic Position: Chr5, Syntenic
• Alliance: Hdp2^Jrt page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdp2 Mutation: 0 strains or lines available

Notes

Heterozygous mice exhibit high ascending aortic peak blood velocity waveforms, stroke distance and mean velocity in vivo. Ultrabiomicroscope ultrasound analysis indicates a narrow outflow tract with myocardial hypertrophy. Pathology findings include aortic and ventricular hypertrophy, ventricular dilation, and aortic valve endocardiosis.

References

• Original: J:88256 Rossant J, ENU mutants from the Center of Modeling Human Disease. MGI Direct Data Submission. 2004
• All: 1 reference(s)