Idd13^NOD/ShiLt
QTL Variant Detail

Summary

• QTL variant: Idd13^NOD/ShiLt
• Name: insulin dependent diabetes susceptibility 13; NOD/ShiLt
• MGI ID: MGI:3036815
• QTL: Idd13 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: NOD/ShiLt

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers defective cytokine response (IL-2, IL-4, IFN-gamma, CSF-2) when stimulated with antigens compared to C57BL/6. (J:85823)

Notes

B6.NOD-Idd13 congenic animals exhibit defective iNKT cell induced IFN-gamma response. This phenotype resembles that of the NOD parental.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:20685

The authors describe the derivation of a diabetes resistant mouse strain, NOR/Lt, used in the identification of a new insulin-dependent diabetes susceptibility locus (Idd13) on Chromosome 2. NOR/Lt is a recombinant congenic strain in which portions of the NOD/Lt genome has been replaced by DNA from the C57BL/KsJ strain. Genotypic analysis of the progeny from a (NOD/Lt x NOR/Lt)F2 cross using the Chi square test indicates that Idd13 maps between B2m and Pcna, very near Il1. This location was confirmed by the analysis of congenic strains where Idd13 from the NOR/Lt strain cosegregates with Il1, D2Mit47 and D2Mit48 onto the NOD/Lt background. Together these studies indicate that the order of loci in this region of Chromosome 2 is: B2m, Idd13, Il1, D2Mit47, D2Mit48. Homozygosity for NOR/Lt-derived alleles confer resistance to IDDM at Idd13.

References

• Original: J:20685 Serreze DV, et al., Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene. J Exp Med. 1994 Oct 1;180(4):1553-8
• All: 4 reference(s)