Tnfp^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Tnfp^DBA/2J
• Name: tumor necrosis factor protection; DBA/2J
• MGI ID: MGI:3036746
• QTL: Tnfp Location: Chr12:103612889-103623471 bp Genetic Position: Chr12, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to TNF-induced lethal shock compared to C57BL/6J. (J:53210)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:53210

24 BXD recombinant inbred (RI) strains were analyzed for loci associated with resistance to TNF-induced lethal shock. Parental strain DBA/2J is resistant to TNF-induced lethal shock whereas parental strain C57BL/6J is susceptible.

A locus named Tnfp (tumor necrosis factor protection) mapped to 54 cM on mouse Chromosome 12 with highest significant linkage to lethality at Serpina6 (LOD=6.9). Tnfp is also linked to Serpina3kr, Serpina3K (LOD=3.3), and Sperina1. Tnfp also showed association with TNF-inducedhypothermia and elevated serum IL-6. DBA/2J-derived alleles confer dominantly-inherited protection from TNF-induced lethal shock.

A locus showing suggestive linkage to TNF-induced hypothermia mapped to mouse Chromosome 2 near Pmv3 (23 cM).

References

• Original: J:53210 Libert C, et al., Identification of a locus on distal mouse chromosome 12 that controls resistance to tumor necrosis factor-induced lethal shock. Genomics. 1999 Feb 1;55(3):284-9
• All: 1 reference(s)