Mhsvr1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Mhsvr1^C57BL/6J
• Name: malignant histiocytosis sarcoma virus resistance 1; C57BL/6J
• MGI ID: MGI:3036727
• QTL: Mhsvr1 Location: unknown Genetic Position: Chr13, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:40894

Analysis of the strain distribution pattern of 25 BXD recombinant inbred (RI) strains identified a locus associated with dominant resistance to the malignant histiocytosis sarcoma virus (MHSV). This locus mapped to 57 cM on mouse Chromosome 13 and is named Mhsvr1. Pmv9 (54 cM) and Iapls3-14 (59 cM) are 2 genes showing significant linkage (95.8% probability) to Mhsvr1. Mhsvr1 is syntenic to human chromosome 5q35, a region that is associated with human malignant histiocytosis (MH).

References

• Original: J:40894 Panoskaltsis-Mortari A, et al., Genetic and immunological parameters governing in vivo susceptibility/resistance to retrovirally induced murine malignant histiocytosis. J Leukoc Biol. 1998 Oct;64(4):441-50
• All: 1 reference(s)