Idd2^NOD/Smrf
QTL Variant Detail

Summary

• QTL variant: Idd2^NOD/Smrf
• Name: insulin dependent diabetes susceptibility 2; NOD/Smrf
• MGI ID: MGI:3036662
• QTL: Idd2 Location: Chr9:99792386-99792481 bp Genetic Position: Chr9, cM position of peak correlated region/allele: 52.24 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NOD/Smrf

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased CD4+ levels compared to NON/Lt. (J:30526)
• Inheritance: Other (see notes)

Notes

Idd2 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:30526

The percentage of circulating CD4+ T Cells in NOD/Smrf mice is 40-50% greater then NON/Lt mice, enabling the investigation of how this quantitative phenotype segregates in a BC1 population (NON/Lt x NOD/Smrf)F1 x NOD/Smrf and in an F2 population (NON/Lt x NOD/Smrf)F1 x (NON/Lt x NOD/Smrf)F1. Statistical analysis using t-tests showed a significant correlation of circulating CD4+ T cells with the mouse Chromosome 9 marker D9Mit12 in both male and female segregants. The gene or genetic region responsible for this phenotype is termed Tlf (T lymphocyte frequency) Importantly, the authors show a correlation of Tlf with diabetic incidence as expressed by NON/Lt and NOD/Smrf mice suggesting that Tlf may in fact be the mouse Chromosome 9 locus Idd2.

References

• Original: J:30526 Pearce RB, et al., Association of an androgen-responsive T cell phenotype with murine diabetes and Idd2. Autoimmunity. 1995;20(4):247-58
• All: 1 reference(s)