Myog^tm1Sjb
Targeted Allele Detail

Summary

• Symbol: Myog^tm1Sjb
• Name: myogenin; targeted mutation 1, Steven J Burden
• MGI ID: MGI:3036561
• Synonyms: myg^T87N
• Gene: Myog Location: Chr1:134217742-134220286 bp, + strand Genetic Position: Chr1, 58.18 cM
• Alliance: Myog^tm1Sjb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88178
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: To disrupt phosphorylation of the encoded protein at threonine 87, a threonine-to-asparagine substitution mutation was engineered in the basic DNA-binding region at codon 87 (T87N) of exon 1. A single frt site remained in intron after the excision of an frt-flanked neo cassette from the germline. Expression of the mutant transcript was verified by Northern blot analysis of homozygous mutant mice. (J:88178)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myog Mutation: 14 strains or lines available

References

• Original: J:88178 Blagden CS, et al., Accelerated response of the myogenin gene to denervation in mutant mice lacking phosphorylation of myogenin at threonine 87. Mol Cell Biol. 2004 Mar;24(5):1983-9
• All: 1 reference(s)