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Sluc1B10.O20/Dem
QTL Variant Detail
Summary
QTL variant: Sluc1B10.O20/Dem
Name: susceptibility to lung cancer 1; B10.O20/Dem
MGI ID: MGI:3033831
QTL: Sluc1  Location: Chr19:36016944-46761521 bp  Genetic Position: Chr19, Syntenic
Variant
origin
Strain of Specimen:  B10.O20/Dem
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:36997

Lung tissue of N-ethyl-N-nitrosourea treated F2 progeny of an (OcB9/Dem x O20/A)F1 intercross was microscopically analyzed for the presence and size of tumors. The progeny were genotyped by PCR. Statistical analysis indicated the presence of a locus influencing susceptibility to lung cancer (Sluc1) on mouse Chromosome 19, distal to the Pas3 region (flanked by D19Mit42 and D19Mit19). The QTL likelihood plot indicates a peak near D19Mit9. The following order of loci was reported: D19Mit42 - D19Mit61- D19Mit63 - D19Mit19 - Sluc1 - D19Mit9 - D19Mit33.

References
Original:  J:71973 Tripodis N, et al., Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. J Natl Cancer Inst. 2001 Oct 3;93(19):1484-91
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory