Sluc19^B10.O20/Dem
QTL Variant Detail

Summary

• QTL variant: Sluc19^B10.O20/Dem
• Name: susceptibility to lung cancer 19; B10.O20/Dem
• MGI ID: MGI:3033808
• QTL: Sluc19 Location: Chr7:128166122-128166379 bp Genetic Position: Chr7, cM position of peak correlated region/allele: 70.29 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: B10.O20/Dem

Variant description

• Allele Type: QTL

Notes

Sluc19 interacts with Sluc27 on mouse Chromosome 16.

Animals homozygous for B10.O20/Dem-derived alleles at Sluc19 and homozygous for O20/A-derived alleles at Sluc27 exhibit increased lung tumor size.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:71973

Several F2 crosses between inbred strain O20/A and recombinant congenic strains OcB-3/Dem, OcB-4/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem were used to map QTLs linked to lung tumor susceptibility. Parental strain O20/A and OcB-4/Dem are susceptible to lung tumor development after ENU treatment whereas parental strains OcB-3/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem are relatively resistant. 14 previously identified lung tumor susceptibility loci were detected in these crosses (Sluc1-Sluc14) and 16 new loci were identified with a statistical significance of P>0.05. All of the QTL were detected in pairwise interactions, Table 1, Fig 1.

In the (OcB16 x O20/A)F2 cross newly identified QTL Sluc19 mapped to Chr 7 in linkage with D7Mit105 at approximately 63.5 cM.

In the (OcB3 x O20/A)F2 cross newly identified Sluc30 mapped to mouse Chr 7 in linkage with D7Mit57 at approximately 4 cM.

References

• Original: J:71973 Tripodis N, et al., Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. J Natl Cancer Inst. 2001 Oct 3;93(19):1484-91
• All: 1 reference(s)