Strbp^{Gt(pGT1.8geo)8Pgr}
Gene trapped Allele Detail

Summary

• Symbol: Strbp^{Gt(pGT1.8geo)8Pgr}
• Name: spermatid perinuclear RNA binding protein; gene trap 8, Peter Gruss
• MGI ID: MGI:3033751
• Synonyms: Spnr^GT
• Gene: Strbp Location: Chr2:37459880-37593890 bp, - strand Genetic Position: Chr2, 24.19 cM, cytoband C1
• Alliance: Strbp^{Gt(pGT1.8geo)8Pgr} page

Mutation origin

• Mutant Cell Line: VII-28
• Germline Transmission: Earliest citation of germline transmission: J:69466
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Gene trapped (Hypomorph, Reporter)
• Mutation: Insertion of gene trap vector Vector: pSABetageo Vector Type: gene trap
• Mutation details: A gene trap vector inserted into the endogenous gene such that the beta-galactosidase and neomycin genes were fused to the expressed mRNA at position 1149. Beta-galactosidase expression was noted in a similar pattern to the wild-type mRNA. RT-PCR analysis indicated that a low level of wild-type transcript was still expressed from this allele, suggesting that this mutation is a hypomorph. (J:69466)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Strbp Mutation: 46 strains or lines available

References

• Original: J:47980 Stoykova A, et al., Gene trap expression and mutational analysis for genes involved in the development of the mammalian nervous system. Dev Dyn. 1998 Jun;212(2):198-213
• All: 2 reference(s)