Cd276^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Cd276^tm1Mak
• Name: CD276 antigen; targeted mutation 1, Tak Mak
• MGI ID: MGI:3033707
• Synonyms: B7-H3^-
• Gene: Cd276 Location: Chr9:58431581-58462720 bp, - strand Genetic Position: Chr9, 31.79 cM
• Alliance: Cd276^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84973
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Homologous recombination was used to replace a 3.2 kb genomic fragment including the exon encoding the second immunoglobulin domain with a neomycin cassette in antisense orientation relative to transcription. RT-PCR and flow cytometric analysis indicated an absence of transcript and protein, respectively, in homozygous mutant MEFs. (J:84973)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd276 Mutation: 21 strains or lines available

References

• Original: J:84973 Suh WK, et al., The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat Immunol. 2003 Sep;4(9):899-906
• All: 8 reference(s)