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QTL Variant Detail
QTL variant: CkdsFVB/N
Name: cystic kidney disease severity; FVB/N
MGI ID: MGI:3033037
QTL: Ckds  Location: unknown  Genetic Position: Chr4, Syntenic
Strain of Specimen:  FVB/N
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased polycystic kidney disease severity compared to C3HeB/FeJLe. (J:73583)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures

Mapping and Phenotype information for this QTL, its variants and associated markers


The oprk mutation (caused by the insertion of transgene TgN737Rpw) on a FVB/N background results in polycystic kidney disease. The same mutation on a C3HeB/FeJLe background results in a less severe polycystic disease phenotype, longer life span, and development of renal cysts at a slower rate compared to the transgenic FVB/N line. Genome scan was performed on a (C3HeB/FeJLe x FVB/N-TgN737Rpw)F1 x FVB/N-TgN737Rpw backcross and (C3HeB/FeJLe x FVB/N-TgN737Rpw)F2 intercross to identify loci modifying polycystic kidney disease severity. A locus on distal chromosome 4 spanning 58 cM - 75 cM was significantly linked to cystic kidney disease severity and was named Ckds. This locus reached LOD = 2.34 in the backcross and LOD = 2.1 in the F2 intercross. FVB/N-derivedalleles confer increased disease severity in a recessive fashion at Ckds.

Original:  J:73583 Sommardahl C, et al., Phenotypic variations of orpk mutation and chromosomal localization of modifiers influencing kidney phenotype. Physiol Genomics. 2001 Dec 21;7(2):127-34
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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