Chrnb3^tm1Sfh
Targeted Allele Detail

Summary

• Symbol: Chrnb3^tm1Sfh
• Name: cholinergic receptor, nicotinic, beta polypeptide 3; targeted mutation 1, Stephen F Heinemann
• MGI ID: MGI:3032611
• Synonyms: beta3^-
• Gene: Chrnb3 Location: Chr8:27858739-27889758 bp, + strand Genetic Position: Chr8, 16.0 cM, cytoband A3
• Alliance: Chrnb3^tm1Sfh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87972
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 5 was interrupted by insertion of an IES-tau-lacZ cassette and a floxed neomycin resistance gene. This resulted in reduced production of mRNA transcription but did not eliminate it entirely. (J:87972)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrnb3 Mutation: 34 strains or lines available

References

• Original: J:87972 Cui C, et al., The beta3 nicotinic receptor subunit: a component of alpha-conotoxin MII-binding nicotinic acetylcholine receptors that modulate dopamine release and related behaviors. J Neurosci. 2003 Dec 3;23(35):11045-53
• All: 8 reference(s)