P2rx2^tm1Ckn
Targeted Allele Detail

Summary

• Symbol: P2rx2^tm1Ckn
• Name: purinergic receptor P2X, ligand-gated ion channel, 2; targeted mutation 1, Debra A Cockayne
• MGI ID: MGI:2687349
• Synonyms: P2X2^-
• Gene: P2rx2 Location: Chr5:110487678-110491078 bp, - strand Genetic Position: Chr5, 53.49 cM
• Alliance: P2rx2^tm1Ckn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88199
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 11 were deleted and replaced by a neomycin resistance cassette by homologous recombination in ES cells. RT-PCR analysis confirmed absence of mRNA in whole brain and testis from homozygous mutant mice, whereas the expected band was obtained in wild-type mice. (J:88199)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any P2rx2 Mutation: 30 strains or lines available

References

• Original: J:88199 Khakh BS, et al., ATP modulation of excitatory synapses onto interneurons. J Neurosci. 2003 Aug 13;23(19):7426-37
• All: 22 reference(s)