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Fabp1tm1Ddsn
Targeted Allele Detail
Summary
Symbol: Fabp1tm1Ddsn
Name: fatty acid binding protein 1, liver; targeted mutation 1, Nicholas O Davidson
MGI ID: MGI:2687013
Synonyms: L-Fabp-
Gene: Fabp1  Location: Chr6:71176863-71182018 bp, + strand  Genetic Position: Chr6, 32.14 cM
Alliance: Fabp1tm1Ddsn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87278
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with GFP and a floxed neomycin cassette. Expression of either mRNA or protein product was undetectable in homozygotes. (J:87278)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fabp1 Mutation:  21 strains or lines available
References
Original:  J:87278 Newberry EP, et al., Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene. J Biol Chem. 2003 Dec 19;278(51):51664-72
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory