Slc27a4^tm1Asta
Targeted Allele Detail

Summary

• Symbol: Slc27a4^tm1Asta
• Name: solute carrier family 27 (fatty acid transporter), member 4; targeted mutation 1, Andreas Stahl
• MGI ID: MGI:2684501
• Gene: Slc27a4 Location: Chr2:29692646-29707534 bp, + strand Genetic Position: Chr2, 20.64 cM, cytoband B
• Alliance: Slc27a4^tm1Asta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86762
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A genomic fragment encompassing exons 1 and 2 was replaced with a cassette containing nls-lacZ and PGK-neo. The deleted sequence encoded the first 185 amino acids of the protein. Heterozygous mutant mice were shown to have approximately half as much protein as wild-type mice by Western blot analysis. (J:86762)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc27a4 Mutation: 33 strains or lines available

References

• Original: J:86762 Gimeno RE, et al., Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J Biol Chem. 2003 Dec 5;278(49):49512-6
• All: 1 reference(s)