Pde7a^{Gt(Betageo-puro)1Yang}
Gene trapped Allele Detail

Summary

• Symbol: Pde7a^{Gt(Betageo-puro)1Yang}
• Name: phosphodiesterase 7A; gene trap 1, Guchen Yang
• MGI ID: MGI:2684009
• Synonyms: PDE7A^-
• Gene: Pde7a Location: Chr3:19277272-19365486 bp, - strand Genetic Position: Chr3, 5.36 cM
• Alliance: Pde7a^{Gt(Betageo-puro)1Yang} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86923
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector containing beta-geo, puro, and flanking long terminal repeats inserted into an intron of the endogenous locus, corresponding with human intron 5. RT-PCR analysis of splenic mRNA indicated an absence of normal transcript in homozygous mutant mice. Though mutant transcript species comprising sequence either 5' or 3' to the gene trap insertion were detected, transcript containing an undisrupted catalytic domain was not detected in homozygous mutant mice. Endogenous enzymatic activity was not detected in homozygous lymph node lysates. (J:86923)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde7a Mutation: 57 strains or lines available

References

• Original: J:86923 Yang G, et al., Phosphodiesterase 7A-deficient mice have functional T cells. J Immunol. 2003 Dec 15;171(12):6414-20
• All: 1 reference(s)