Cdk5r1^tm1Ivi
Targeted Allele Detail

Summary

• Symbol: Cdk5r1^tm1Ivi
• Name: cyclin dependent kinase 5, regulatory subunit 1; targeted mutation 1, Inez Vincent
• MGI ID: MGI:2683302
• Synonyms: p35^-
• Gene: Cdk5r1 Location: Chr11:80367849-80372010 bp, + strand Genetic Position: Chr11, 47.94 cM
• Alliance: Cdk5r1^tm1Ivi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86345
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.5 kb fragment of the gene containing all of the coding region was replaced with a neomycin resistance cassette in reverse orientation. Protein product was undetectable in homozygotes by Western blot analysis. (J:86345)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk5r1 Mutation: 17 strains or lines available

References

• Original: J:86345 Hallows JL, et al., Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice. J Neurosci. 2003 Nov 19;23(33):10633-44
• All: 12 reference(s)