Hmmr^tm1Baa
Targeted Allele Detail

Summary

• Symbol: Hmmr^tm1Baa
• Name: hyaluronan mediated motility receptor (RHAMM); targeted mutation 1, Benjamin A Alman
• MGI ID: MGI:2682898
• Synonyms: Rhamm-
• Gene: Hmmr Location: Chr11:40592222-40624249 bp, - strand Genetic Position: Chr11, 24.4 cM
• Alliance: Hmmr^tm1Baa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86065
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment encompassing exons 8 through 16 was replaced with a Hprt minigene. Full length transcript was undetected by RT-PCR analysis of homozygous mutant spleen tissue. Analysis of homozygous mutant MEFs identified aberrant transcript in which exon 7 had spliced to exon 17. Sequence analysis indicated a frameshift mutation at the aberrant splice junction, affecting downstream sequence encoding the HA-binding region. Western blot analyses of homozygous spleen tissue and MEFs did not detect protein corresponding with the mutant transcript. (J:86065)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmmr Mutation: 45 strains or lines available

References

• Original: J:86065 Tolg C, et al., Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor). Oncogene. 2003 Oct 9;22(44):6873-82
• All: 8 reference(s)