Ins2^tm2Jja
Targeted Allele Detail

Summary

• Symbol: Ins2^tm2Jja
• Name: insulin II; targeted mutation 2, Jacques Jami
• MGI ID: MGI:2682233
• Synonyms: Ins2^Neo
• Gene: Ins2 Location: Chr7:142232393-142233463 bp, - strand Genetic Position: Chr7, 88.0 cM
• Alliance: Ins2^tm2Jja page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45695
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The promoter and majority of the coding sequences were replaced with a Neo cassette driven by the thymidine kinase promoter of herpes simplex virus and the polyoma T-antigen gene enhancer. The expression of Neo was determined by RT-PCR in embryonic yolk sacs. (J:45695)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:

12 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ins2 Mutation: 93 strains or lines available

References

• Original: J:45695 Duvillie B, et al., Imprinting at the mouse Ins2 locus: evidence for cis- and trans-allelic interactions. Genomics. 1998 Jan 1;47(1):52-7
• All: 1 reference(s)