Cd38^tm1Okam
Targeted Allele Detail

Summary

• Symbol: Cd38^tm1Okam
• Name: CD38 antigen; targeted mutation 1, Hiroshi Okamoto
• MGI ID: MGI:2680868
• Synonyms: CD38^-
• Gene: Cd38 Location: Chr5:44026153-44069714 bp, + strand Genetic Position: Chr5, 23.85 cM
• Alliance: Cd38^tm1Okam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52933
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was flanked by single loxP sites and subsequently excised via cre mediated recombination, leaving a single loxP site in place of exon 1. Transcript was undetected in homozygous mutant mice by RT-PCR analysis of pancreatic RNA. Western blot analysis indicated an absence of protein. (J:52933)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd38 Mutation: 50 strains or lines available

References

• Original: J:52933 Kato I, et al., CD38 disruption impairs glucose-induced increases in cyclic ADP-ribose, [Ca2+]i, and insulin secretion. J Biol Chem. 1999 Jan 22;274(4):1869-72
• All: 21 reference(s)