Cblc^tm1Pngr
Targeted Allele Detail

Summary

• Symbol: Cblc^tm1Pngr
• Name: Casitas B-lineage lymphoma c; targeted mutation 1, Josef M Penninger
• MGI ID: MGI:2680200
• Synonyms: Cbl-3^-
• Gene: Cblc Location: Chr7:19513643-19530734 bp, - strand Genetic Position: Chr7, 9.94 cM, cytoband A2
• Alliance: Cblc^tm1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86267
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a cassette containing lacZ and neo. Transcript was undetected in homozygous mutant mice by Northern blot analysis of RNA obtained from the small intestine and the colon. The expression pattern of lacZ was realized by X-gal staining and was similar to that of the endogenous gene. (J:86267)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cblc Mutation: 27 strains or lines available

References

• Original: J:86267 Griffiths EK, et al., Cbl-3-deficient mice exhibit normal epithelial development. Mol Cell Biol. 2003 Nov;23(21):7708-18
• All: 1 reference(s)