Cnga4^tm1Reed
Targeted Allele Detail

Summary

• Symbol: Cnga4^tm1Reed
• Name: cyclic nucleotide gated channel alpha 4; targeted mutation 1, Randall R Reed
• MGI ID: MGI:2680015
• Synonyms: CNGA4^-
• Gene: Cnga4 Location: Chr7:105053775-105057949 bp, + strand Genetic Position: Chr7, 55.85 cM
• Alliance: Cnga4^tm1Reed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83225
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons encoding the pore region, 2 transmembrane domains, and the cyclic nucleotide-binding region were replaced with a cassette containing tau-lacZ. A floxed region included in the targeting vector containing a partially deleted thymidine kinase gene and a neomycin resistant gene was excised via cre mediated recombination. Transcript was undetected by in situ hybridization of homozygous mutant olfactory receptor neurons. (J:83225)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cnga4 Mutation: 34 strains or lines available

References

• Original: J:83225 Munger SD, et al., Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. Science. 2001 Dec 7;294(5549):2172-5
• All: 2 reference(s)