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QTL Variant Detail
QTL variant: Bis1C3HeB/FeJ
Name: beta-carboline-induced seizures 1; C3HeB/FeJ
MGI ID: MGI:2679862
Synonyms: Bis1C3XtEso/Gnc
QTL: Bis1  Location: Chr4:136864433-136864536 bp  Genetic Position: Chr4, cM position of peak correlated region/allele: 69.44 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C3HeB/FeJ
Allele Type:    QTL
Inheritance:    Not Specified

Mapping and Phenotype information for this QTL, its variants and associated markers


The authors analyzed six mouse strains for susceptibility to (beta)-carboline induced seizures, of which only two gave significant results. In one strain, Je/LeGnc, theauthors detected an association between Bis1 and je. Analysis of (C3XtEso/Gnc x Je/LeGnc)F1 backcross and intercross progeny confirmed the mapping of Bis1 to within ~3.1 cM of je on mouse Chromsome 4.


The authors examined the gentic basis of differences in seizure behaviour using a GABAa receptor agoinst beta CCM (methyl beta-carboline-3 carboxylate). A/J mice are more susceptible to beta-CCM induced myoclonic seizures than C57BL/6J mice in both latency to seizure and proportion of tested mice that seized. The previously identified Bis1 QTL was confirmed in a subsequent backcross population (n = 223), D4Mit68 on distal Chromosome 4 is associated with seizure susceptibility (chi square = 10.3; p<0.0012; n = 217) and seizure latency. A LOD score = 2.88 was assigned to this locus and it accounted for 6-9% of the phenotypic variance for this seizure trait. The best-fitting logistic regression model suggests that the C57BL/6J allele at the D4Mit68 locus increased the likelihood of resistance to seizures at 23 fold. Candidate genes in this region include Htr1da, Htr1db and Slc9a1.

Original:  J:28058 Martin B, et al., Mouse chromosomes 4 and 13 are involved in beta-carboline-induced seizures. J Hered. 1995 Jul-Aug;86(4):274-9
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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