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Targeted Allele Detail
Symbol: Klk8tm1Shio
Name: kallikrein related-peptidase 8; targeted mutation 1, Sadao Shiosaka
MGI ID: MGI:2678312
Synonyms: Neuropsin-, NP-
Gene: Klk8  Location: Chr7:43447001-43453250 bp, + strand  Genetic Position: Chr7, 28.26 cM, cytoband B4
Alliance: Klk8tm1Shio page
Germline Transmission:  Earliest citation of germline transmission: J:68653
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 through 3 were replaced with a neomycin selection cassette. The deleted region encoded histidine at postion 57 and aspartate 102 which are essential for catalytic activity. Transcript was undetected by Northern blot analysis of homozygous mutant mice. Neuropsin activity was undetected in immunoprecipitate from hippocampal homogenate obtained from homozygous mutant mice. (J:68653)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Klk8 Mutation:  22 strains or lines available
Original:  J:68653 Hirata A, et al., Abnormalities of synapses and neurons in the hippocampus of neuropsin-deficient mice. Mol Cell Neurosci. 2001 Mar;17(3):600-10
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory