Pask^tm1Weng
Targeted Allele Detail

Summary

• Symbol: Pask^tm1Weng
• Name: PAS domain containing serine/threonine kinase; targeted mutation 1, Roland H Wenger
• MGI ID: MGI:2677908
• Synonyms: PASK^-, Paskin^-
• Gene: Pask Location: Chr1:93237159-93271244 bp, - strand Genetic Position: Chr1, 47.24 cM, cytoband D
• Alliance: Pask^tm1Weng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85762
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 10 through 14 were replace with a cassette containing a splice acceptor site and IRES-beta-geo. Norhtern blot analysis of various tissues confirmed the absence of endogenous transcript and identified mutant transcript containing the beta-geo squenence. (J:85762)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pask Mutation: 54 strains or lines available

References

• Original: J:85762 Katschinski DM, et al., Targeted disruption of the mouse PAS domain serine/threonine kinase PASKIN. Mol Cell Biol. 2003 Oct;23(19):6780-9
• All: 9 reference(s)