Efnb2^tm1Nwg
Targeted Allele Detail

Summary

• Symbol: Efnb2^tm1Nwg
• Name: ephrin B2; targeted mutation 1, Nicholas W Gale
• MGI ID: MGI:2677368
• Synonyms: ephrin-B2/LacZ, Ephrin-B2^lacZ
• Gene: Efnb2 Location: Chr8:8667434-8711242 bp, - strand Genetic Position: Chr8, 3.42 cM
• Alliance: Efnb2^tm1Nwg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67371
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A region of the gene comprising 281 nucleotides and including the transcription start site and signal sequence was replaced by lacZ and neomycin resistance genes. LacZ expression under the control of the endogenous gene promoter was confirmed immunohistochemically and by in situ hybridization. (J:67371)

Expression

In Mice Carrying this Mutation:

18 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Efnb2 Mutation: 27 strains or lines available

References

• Original: J:67371 Gale NW, et al., Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. Dev Biol. 2001 Feb 15;230(2):151-60
• All: 3 reference(s)