Slc10a2^tm1Pda
Targeted Allele Detail

Summary

• Symbol: Slc10a2^tm1Pda
• Name: solute carrier family 10, member 2; targeted mutation 1, Paul A Dawson
• MGI ID: MGI:2676307
• Synonyms: Asbt^-, Slc10a2^-/-
• Gene: Slc10a2 Location: Chr8:5133219-5155287 bp, - strand Genetic Position: Chr8, 2.16 cM
• Alliance: Slc10a2^tm1Pda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85312
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A region of the gene extending from intron 2 through to the splice acceptor site of exon 4 was replaced with a neomycin resistance cassette. Absence of gene products was confirmed by Northern blots and by immunoblots. (J:85312)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Slc10a2^tm1Pda

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc10a2 Mutation: 26 strains or lines available

References

• Original: J:85312 Dawson PA, et al., Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice. J Biol Chem. 2003 Sep 5;278(36):33920-7
• All: 15 reference(s)