Nr2c1^tm1Chc
Targeted Allele Detail

Summary

• Symbol: Nr2c1^tm1Chc
• Name: nuclear receptor subfamily 2, group C, member 1; targeted mutation 1, Chawnshang Chang
• MGI ID: MGI:2675740
• Synonyms: Nr2c1^tm1Che, TR2 -
• Gene: Nr2c1 Location: Chr10:93983885-94033073 bp, + strand Genetic Position: Chr10, 48.81 cM
• Alliance: Nr2c1^tm1Chc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77023
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ gene and neomycin selection cassette replaced a genomic fragment containing most of exon 4 and all of exon 5. Northern blot analysis on RNA derived from testis tissue of homozygous mice demonstrated that no detectable transcript was expressed from this allele. (J:77023)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr2c1 Mutation: 77 strains or lines available

References

• Original: J:77023 Shyr CR, et al., Spermatogenesis and testis development are normal in mice lacking testicular orphan nuclear receptor 2. Mol Cell Biol. 2002 Jul;22(13):4661-6
• All: 5 reference(s)