Meox1^{Tg(Mx1-TAX)2627Arnh}
Transgenic Allele Detail

Summary

• Symbol: Meox1^{Tg(Mx1-TAX)2627Arnh}
• Name: mesenchyme homeobox 1; transgene insertion 2627, Heinz Arnheiter
• MGI ID: MGI:2674268
• Synonyms: Meox1^im, Meox1^TgN2627ARN
• Gene: Meox1 Location: Chr11:101768336-101785200 bp, - strand Genetic Position: Chr11, Syntenic
• Alliance: Meox1^{Tg(Mx1-TAX)2627Arnh} page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Null/knockout)
• Inducer: interferon or polyinosinic-polycytidylic acid
• Mutation: Insertion
• Mutation details: A null allele was generated when 45.4 kb of the endogenous locus were deleted by the random insertion of a transgenic construct. The deleted region extended from within intron 1 to 31.2 kb downstream of the stop codon. The transgenic construct was comprised of an inducible murine Mx1 promoter adjoined to human T cell leukemia virus type 1 (HTLV1) Tax followed by intron 2 and non-coding exon 3 of the murine beta-globin locus. Endogenous transcript was reported to be undetected in homozygous mutant mice. (J:84754)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Meox1 Mutation: 17 strains or lines available

References

• Original: J:84754 Mankoo BS, et al., The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites. Development. 2003 Oct;130(19):4655-64
• All: 2 reference(s)