Nr0b2^tm1Ddm
Targeted Allele Detail

Summary

• Symbol: Nr0b2^tm1Ddm
• Name: nuclear receptor subfamily 0, group B, member 2; targeted mutation 1, David D Moore
• MGI ID: MGI:2671111
• Synonyms: SHP -
• Gene: Nr0b2 Location: Chr4:133280687-133283847 bp, + strand Genetic Position: Chr4, 66.25 cM
• Alliance: Nr0b2^tm1Ddm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77065
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a lacZ gene and neomycin selection cassette. Northern blot analysis demonstrated that no detectable transcript was present in liver RNA derived from homozygous mice. (J:77065)

Expression

In Mice Carrying this Mutation:	7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr0b2 Mutation: 15 strains or lines available

References

• Original: J:77065 Wang L, et al., Redundant pathways for negative feedback regulation of bile acid production. Dev Cell. 2002 Jun;2(6):721-31
• All: 50 reference(s)