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Gpamtm1Rcol
Targeted Allele Detail
Summary
Symbol: Gpamtm1Rcol
Name: glycerol-3-phosphate acyltransferase, mitochondrial; targeted mutation 1, Rosalind Coleman
MGI ID: MGI:2669956
Synonyms: Gpat1-, mtGPAT-
Gene: Gpam  Location: Chr19:55056067-55115751 bp, - strand  Genetic Position: Chr19, 50.81 cM
Alliance: Gpamtm1Rcol page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84541
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 0.5 kb genomic fragment encoding 62 amino acids including those that make up homology regions II and III was replaced with a neo cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of homozygous mutant liver tissue. Activity assays indicated a near comlpete ablation of endogenous activity and showed that the activity of the microsomal isoform was unperturbed. (J:84541)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gpam Mutation:  37 strains or lines available
References
Original:  J:84541 Hammond LE, et al., Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition. Mol Cell Biol. 2002 Dec;22(23):8204-14
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory