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QTL Variant Detail
QTL variant: LtryC57BL/6ByJ
Name: laterality; C57BL/6ByJ
MGI ID: MGI:2669865
QTL: Ltry  Location: unknown  Genetic Position: Chr4, Syntenic
Strain of Specimen:  C57BL/6ByJ
Allele Type:    QTL
Mutation:    Undefined
Mutation detailsThis allele confers high forepaw and hindpaw laterality values and low plasma lutenizing hormone concentration compared to NZB/BlNJ.

Mapping and Phenotype information for this QTL, its variants and associated markers


Genome scan was performed on 283 (C57BL/6ByJ x NZB/BlNJ)F2 animals using 67 microsatellite markers to identify QTLs associated with right-left paw laterality. Parental strain NZB/BlNJ is more ambidextrous in both the forepaw and hindpaw compared to parental strain C57BL/6ByJ.

A significant locus was identified on mouse Chromosome 4 and named Ltry (laterality). This locus is linked to forepaw laterality at 48 cM (LOD=5.6 at D4Mit205a), and is linked to hindpaw laterality at 49.7 cM (LOD=7.2 at D4Mit12).Ltry is also linked to plasma lutenizing hormone concentration (PLHC) at 48.8 cM with LOD=4.4. The QTL interval of Ltry spans approximately 30 cM - 63 cM. Low forepaw and hindpaw laterality values and high PLHC values are associated with the NZB/BlNJ-derived allele. A possible candidate gene for Ltry is the leptin receptor, Lepr. This gene maps to 46.7 cM on mouse Chromosome 4 and has been implicated in the gonadal steroid cycle.

Original:  J:82664 Roubertoux PL, et al., Analysis of quantitative trait Loci for behavioral laterality in mice. Genetics. 2003 Mar;163(3):1023-30
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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