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Loco1KJR/Ms
QTL Variant Detail
Summary
QTL variant: Loco1KJR/Ms
Name: locomotor activity 1; KJR/Ms
MGI ID: MGI:2669266
QTL: Loco1  Location: Chr3:150461893-150462042 bp  Genetic Position: Chr3, cM position of peak correlated region/allele: 76.65 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  KJR/Ms
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased spontaneous activity compared to BLG2/Ms. (J:78169)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:78169

Two separate backcross populations were analyzed for loci associated with spontaneous activity. Parental strains NJL/Ms and KJR/Ms are hyperactive whereas parental strain BLG2/Ms is hypoactive. 93 polymorphic markers at an average spacing of 20 cM were screened in (KJR/Ms x BLG2/Ms)F1 x BLG2/Ms and (NJL/Ms x BLG2/Ms)F1 x BLG2/Ms backcross populations.

A locus reached peak significance in the (KJR/Ms x BLG2/Ms)F1 x BLG2/Ms population at D3Mit128 (83.5 cM, LOD=4.8) on mouse Chromosome 3 and was named Loco1. KJR/Ms-derived alleles appear to confer increased activity at this locus.

A second locus mapped to mouse Chromosome 17 at D17Mit168 (23 cM, LOD=2.2) in the (KJR/Ms x BLG2/Ms)F1 x BLG2/Ms population and was named Loco2. This locus interacts epistatically with Loco1. KJR/Ms-derived alleles confer increased activity at Loco2 only when KJR/Ms alleles are also present at Loco1.

Linkage analysis of the (NJL/Ms x BLG2/Ms)F1 x BLG2/Ms backcross population did not yield any QTLs.

References
Original:  J:78169 Furuse T, et al., QTL analyses of spontaneous activity by using mouse strains from Mishima battery. Mamm Genome. 2002 Aug;13(8):411-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/17/2023
MGI 6.22
The Jackson Laboratory