Gria3^tm1Zpj
Targeted Allele Detail

Summary

• Symbol: Gria3^tm1Zpj
• Name: glutamate receptor, ionotropic, AMPA3 (alpha 3); targeted mutation 1, Zhengping Jia
• MGI ID: MGI:2668336
• Synonyms: GluR3-
• Gene: Gria3 Location: ChrX:40489731-40767478 bp, + strand Genetic Position: ChrX, 23.19 cM
• Alliance: Gria3^tm1Zpj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84336
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A 1.8kb PGK-neomycin cassette was inserted in the "sense" orientation into exon 12 which contains the TM1 and TM2 domains. No detectable mRNA was found in whole brain lysates of homozygotes and the absence of gene product was proven immunologically. (J:84336)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gria3 Mutation: 10 strains or lines available

References

• Original: J:84336 Meng Y, et al., Synaptic transmission and plasticity in the absence of AMPA glutamate receptor GluR2 and GluR3. Neuron. 2003 Jul 3;39(1):163-76
• All: 6 reference(s)