Ahr^d
Allele Detail

Summary

• Symbol: Ahr^d
• Name: aryl-hydrocarbon receptor; d variant
• MGI ID: MGI:2667196
• Synonyms: ah, Ah^d, Ahhⁿ, Ah^k, AhRd, in
• Gene: Ahr Location: Chr12:35547978-35584988 bp, - strand Genetic Position: Chr12, 15.78 cM
• Alliance: Ahr^d page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Not Applicable
• Mutation: Nucleotide substitutions
• Mutation details: This allele encodes a 104 kDa receptor that is stabilized by molybdate and has an affinity for ligand 10-100 fold lower than that of the receptor produced by the C57BL/6J allele. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, an apparent T to C transition replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the DBA/2J allele. This change would extend translation of the DBA/2J mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa vs 95 kDa for the C57BL/6J allele). A second T to C transition changes a leucine codon in the C57BL/6J allele to a proline codon in the DBA/2J allele, and would likely change secondary structure of the peptide and thus ligand affinity. (J:15153, J:17460, J:22144)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 20 strains available Cell Lines: 0 lines available
• Carrying any Ahr Mutation: 93 strains or lines available

Notes

Strain of origin - this allele was found in DBA/2J, AKR/J, 129, SWR, RF, NZB strains

References

• Original: J:26440 Schmid FA, et al., Toxicity of intraperitoneal injections of 7, 12-dimethylbenz[a]anthracene in inbred mice. Cancer Res. 1967 Mar;27(3):558-62
• All: 66 reference(s)